ST14 Gene Variant and Decreased Matriptase Protein Expression Predict Poor Breast Cancer Survival
نویسندگان
چکیده
منابع مشابه
ression Predict Poor Breast Cancer Survival
ownloade kground: Matriptase plays a role in carcinogenesis, but the role of its genetic variation or that of the cyte growth factor activator inhibitor-1 (HAI-1) has not been evaluated. This study aimed to examine netic variation of matriptase (ST14 gene) and HAI-1 (SPINT1 gene) in breast cancer risk and prognosis, ess matriptase and HAI-1 gene and protein expression in breast tumors, and to i...
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In this article (Cancer Res 2012;72:5537–46), which was published in theNovember 1, 2012, issue of Cancer Research (1), in the last paragraph of the Results section, the sentence ". . .the SRXN1 rs6053666 rare homozygous genotype CC predicted better prognosis than the common allele carriers. . ." should read ". . .the SRXN1 rs6053666 common homozygous genotype TT predicted better prognosis than...
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Overexpression of matriptase has been reported in a variety of human cancers and is sufficient to trigger tumor formation in mice, but the importance of matriptase in breast cancer remains unclear. We analysed matriptase expression in 16 human breast cancer cell lines and in 107 primary breast tumors. The data revealed considerable diversity in the expression level of this protein indicating th...
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The extensive heterogeneity of breast cancer complicates the precise assessment of tumour aggressiveness, making therapeutic decisions difficult and treatments inappropriate in some cases. Consequently, the long-term metastasis-free survival rate of patients receiving adjuvant chemotherapy is only 60%. There is a genuine need to identify parameters that might accurately predict the effectivenes...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2010
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-10-0418